Comparing Esketamine to Antidepressants: Discovering the Ideal Depression Treatment for You
Depression is a tightly-knit struggle for more than 17 million adults in the United States every year, and countless others remain untreated. One primary reason for this reluctance is the ineffectiveness of treatments, with 10% to 30% of depression patients abandoning their medications in frustration.
For those facing treatment-resistant depression, healthcare providers may introduce Esketamine, a potent derivative of the anesthetic ketamine. FDA-approved since March 2019, Esketamine, marketed as Spravato, is a nasal spray used in conjunction with an oral antidepressant for adults with treatment-resistant depression.
Clinical studies have shown exceptional results for people using Esketamine along with an antidepressant. They often found that their depressive symptoms were better managed. However, the FDA's approval for Esketamine is limited, and only patients who have tried at least two other antidepressants for a minimum of six weeks each, without experiencing remission or a 50% improvement, are candidates for this treatment.
Esketamine carries a risk of abuse and psychological and physical dependence. This is one of the reasons it's crucial to stay in close contact with a doctor while on the medication. Just like antidepressants, stopping Esketamine suddenly can cause withdrawal symptoms.
Comparing Esketamine to traditional antidepressants, we find that Esketamine operates differently, increasing glutamate levels in the brain, while antidepressants primarily target serotonin, norepinephrine, and dopamine. This approach allows Esketamine to more profoundly impact brain cells and provide faster relief, with some improvements noticeable within hours to days.
On the other hand, traditional antidepressants can have unpleasant side effects that don't go away, like sexual side effects. Esketamine's effects are temporary, usually lasting a few hours. However, side effects for some people may include drowsiness, dizziness, and feelings of unreality.
Esketamine must be administered by specially trained medical personnel in a certified clinical setting. Unlike antidepressants, which can be self-administered at home, Esketamine's unique properties and side effects require closer supervision.
In short, the question of which is better—Esketamine or traditional antidepressants—depends on the individual. The success rate of Esketamine is remarkable, with approximately 70% of patients experiencing a 50% or more reduction in depressive symptoms and about 50% experiencing total remission. However, many people find relief from symptoms of depression with traditional antidepressants as well. The crucial factor is finding a treatment plan that is effective and has the least possible impact on your life.
When seeking mental health care, look for a psychiatrist with expertise in treating depression. The right doctor will work with you to find an effective treatment plan tailored to your needs and will keep you actively engaged in your mental health care. Whether you choose traditional antidepressants, Esketamine, or a combination, finding a healthcare provider who listens and supports you is essential.
- Encountering treatment-resistant depression can be challenging, and for such cases, healthcare providers might suggest Esketamine, a novel treatment that operates differently than traditional antidepressants, due to its ability to significantly impact brain cells and provide quicker relief.
- In the realm of health-and-wellness and mental health, the science behind Esketamine, a potent derivative of ketamine, is remarkable, as it targets mental health concerns like treatment-resistant depression by increasing glutamate levels in the brain.
- While Esketamine has demonstrated promising results, with around 70% of patients experiencing a 50% or more reduction in depressive symptoms and about 50% experiencing total remission, it is important to note that traditional therapies and treatments for mental health conditions, including antidepressants, can also be effective. The key lies in finding a personalized treatment plan that aligns with your needs and lifestyle, which can be achieved by seeking the advice of an expert in mental-health and working closely with a healthcare provider.
